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Evaluation of pathological characteristics in patients with PA-induced liver injury between liver biopsies at diagnosis and recovery.

Journal: Journal of Clinical and Translational Hepatology

Article Title: Clinicopathological Evolution of Pyrrolizidine Alkaloid-induced Liver Injury: Transition From SOS to PSVD?

doi: 10.14218/JCTH.2026.00077

Figure Lengend Snippet: Evaluation of pathological characteristics in patients with PA-induced liver injury between liver biopsies at diagnosis and recovery.

Article Snippet: Antibodies against CD34 (Proteintech, 14486-1-AP) and CD34 (Servicebio, GB15013) were used for human and rat IHC, respectively.

Techniques: Biomarker Discovery, Staining

(A) Flowchart of the construction of the PA-induced SOS model. (B) Serum ALT and AST levels in the five groups. (C) H&E histopathological sections of representative livers from the five groups. (D) Sirius red histopathological sections of representative livers from the five groups. (E) CD34 histopathological sections of representative livers from the five groups. n = 5/group. ns, not significant; *** P < 0.001; **** P < 0.0001. PA, pyrrolizidine alkaloid; ALT, alanine aminotransferase; AST, aspartate aminotransferase; PT, portal tract; CV, central vein; SOS, sinusoidal obstruction syndrome. HE, hematoxylin and eosin.

Journal: Journal of Clinical and Translational Hepatology

Article Title: Clinicopathological Evolution of Pyrrolizidine Alkaloid-induced Liver Injury: Transition From SOS to PSVD?

doi: 10.14218/JCTH.2026.00077

Figure Lengend Snippet: (A) Flowchart of the construction of the PA-induced SOS model. (B) Serum ALT and AST levels in the five groups. (C) H&E histopathological sections of representative livers from the five groups. (D) Sirius red histopathological sections of representative livers from the five groups. (E) CD34 histopathological sections of representative livers from the five groups. n = 5/group. ns, not significant; *** P < 0.001; **** P < 0.0001. PA, pyrrolizidine alkaloid; ALT, alanine aminotransferase; AST, aspartate aminotransferase; PT, portal tract; CV, central vein; SOS, sinusoidal obstruction syndrome. HE, hematoxylin and eosin.

Article Snippet: Antibodies against CD34 (Proteintech, 14486-1-AP) and CD34 (Servicebio, GB15013) were used for human and rat IHC, respectively.

Techniques: